Drop in customer and target market for a beverage operation Assignment

Drop in customer and target market for a beverage operation - Assignment Example In this paper I will be using drop-in-customer as my customer type and analysing the target market in relation to selection of location for a beverage operation. Energy boosting beverages are largely consumed by sports persons such as athletes. However, the market for these beverages has grown and expanded beyond sports persons to attract non-traditional drinkers. Teenagers, college students and young adults in the ages of 18 to 34 account for majority of energy drink consumption today. This is particularly because of this population’s active lifestyle. Furthermore advertisements for such products appeal to this generation more as compared to older persons. Research has shown that 34% of persons between the ages of 18 and 24 take energy drinks regularly (O’Brien et al, 2008). Also half of all college students consume a drink at least every month regardless of their gender. Most drop-in-customers for beverages are therefore below the age of 34 years of age, are active and therefore will take an energy drink especially on a tiresome day (Heckman, Sherry and Gonzalez, 2010). Sports persons also actively consumer energy drinks. This target market many not have lots of money to spend but regularly need the drinks and will therefore often purchase a drink. The young adults on the other hand are mostly in their first jobs and therefore have some funds to spend on drinks. Marketing and advertisement messages should therefore communicate the benefits of the drinks and at the same time appeal in terms of price (Miller, 2008). Location for beverage operations is also an important element of marketing considering the demographics of the target market. The on-the-go life style of the target market for instance requires that operations are located in strategic places such as supermarkets, college canteens and central places on streets. Design of the retail outlets should also take in account the fact that these

Rizal Life Essay Example for Free

Rizal Life Essay The Jesuits, on the other hand, were with him practically every minute of the time, six priests going in relays, usually two at a time, in an attempt to bring about Rizals conversion. They have written the only complete story about his last day. Their earliest account was published in Spain in 1897; it is found in chapter seventeen of a book called La Masonizacion de Filipinas, Rizal y su Orba, printed by Tipografica Catolica of Barcelona. The author is anonymous but is thought to have been Father Pastalls. 03) In starting chapter seventeen he says: We will relate the fascinatingly interesting incidents as furnished to us from a new unedited and authentic account received from Manila. The account deals so largely with Father Balaguer, that it probably depended upon the notes Father Balaguer said he kept. (04) How far can we rely upon the accuracy and fairness of this book? Fortunately, we have a means of judging it. The first sixteen chapters deal with the life of Rizal which we have already studied. It says he was a model youth until he went to Europe to study medicine. There he joined Masonic lodges where he heard Republicans declare, Liberty should be demanded with bullets and not on ones knees. Ideas like this turned him into a fierce revolutionist. The book finds not a single wrong in the Philippines; but finds several governor-generals too lenient! It says that the liberal Governor Terrero was so weak that the religious orders had to hound him out of the Islands. 05) Governor General [Valeriano] Weyler (the bloody Weyler of Cuba) was an ideal governor who knew how to attack with firmness the evils permitted in the time of the weak Terrero. To use his graphic phrase he sucked out the brains of those he captured, so that the insurrection could not raise its head nor Masonry make any gains (06) . . . If only Rizal had remained in the Philippines and studied agriculture he would not have become the scandalizer and corruptor of his people. (07) The book strikes that note throughout, concerning Rizal and his most miserable work. (08) He was completely wrong, Spain beautifully right, but too mild at times; not injustice, but Masonry and Germany led Rizal to write his books indeed, most of the conclusions are diametrically opposite to the truth. One is prepared by this distortion of facts to be on his guard in reading the chapter on Rizals last day. Father Pio Pi, who succeeded Father Pastells, and was head of the Jesuit order in 1896, but not personally acquainted with Rizal, wrote a little book in 1909, calledLa Muerte Christiana de Doctor Rizal. 09) This follows the anonymous book of 1897 closely, often quoting word for word, but adding other details. (10) Father Balaguer, who says he secured Rizals retraction, signed (11) a sworn statement in 1917 in which he says: If anyone judges that I could not remember so many details, after twenty years, I may say that the same day in which Rizal died I wrote a very detailed story, the entire original of which I saved, and I have borrowed from it to make the present statement. All three writers evidently depend upon the notes of Father Balaguer for the most disputed part of the story. 12) Because the controversy as to whether Rizal did retract is so intense, it will be interesting to read the essential portions of the narrative, in an effort to get at the truth. It was what Retana calls El Dia Supremo for the Jesuits. They had worked with Rizal for four years without visible results. Following a well-conceived and well-executed plan, the government had touched his heart with the sufferings of his relatives, with exasperating espionage, with alternating laxity and severity, with heart-breaking disappointments, with loneliness, while the Jesuit fathers tried to win him with kindness and arguments. They had apparently failed. Now they had twenty-four hours or never! Father Pio Pi writes that the Archbishop showed great eagerness for the conversion of the man sentenced to death, and granted us all his authority to do whatever might be necessary. He directed us also to prepare a retraction, in the hope that the condemned man might be willing to accept and sign it; and we agreed to do so and to present it for his approval. . . . As usual, the Jesuits went at their task with tremendous fervor. From seven oclock of December 29, when Rizal was notified of his sentence, until he fell dead, there were few moments when they were not with him, coming in pairs and marshalling every means they could think of to play upon his emotions, to appeal to his reason, and to terrify him when other methods failed. Rizals statue: The Sacred Heart of Christ The rector of the Ateneo, Father Miguel Saderra Mata, and one of the professors, Father Luis Viza, took with them an image of the Sacred Heart of Christ, which Rizal had carved when he was a student in the Ateneo. Look, said the Father, how the heart of Jesus has been here twenty years waiting for Rizal. It wishes to convert him. Pi says that Rizal took it and put it on his table, where it remained until after his execution. Then Father Antonio Rosell was with the prisoner for awhile, and returned with a bad impression; he believed from what he heard that the man was a Protestant. Father [Federico] Faura also visited him that morning. Riz al asked as soon as he entered, Do you recall, Father, the last time we talked and what you foretold? It has come to pass. You are a prophet; I am going to die on the scaffold. Padre Faura could not subdue that spirit, still rebelling against the appeals of grace; so much so that the Father retired broken up with grief. From Rizal y su Obra (13) comes an account which sounds true, for there could have been no object in inventing the story: Father Balaguer returned to the chapel to discuss the religious question with the prisoner. The symptoms were very sad; there was little hope. In the morning when he had been given a medal of the Holy Virgin, he took it, probably from courtesy, and said coldly: I am a little Marian. Unfortunate man! To such an extreme, because of his error, had the former secretary of the Marian Congregation fallen. And yet he did not desire to abandon Her whom he had formerly served with filial love. Concerning religion, Rizal began to speak with reverence of God, of our Lord Jesus Christ, of the Holy Gospel, and of the Sacred Scriptures; he said that he prayed, and that he was always asking God for light, as his only wish was to fulfill his Holy Will. . He seemed like a fervent probationer. But observing that his statements were those that a Protestant would make, Father Balaguer narrowed him down to concrete and categorical questions, which showed that Rizal did not admit the authority of the Roman church nor of the Pontificate, and held as his rule of faith, the Scriptures as interpreted by his judgment, in short that he seemed to be guided by a Protestant criterion, but mixed in reality with free thinking and a strange piety. Father Balaguer, who had been with Rizal inDapitan, is the man who claims that he secured the retraction. We will let him tell his own story as to how he did it: I, who knew the history of his errors and what his books contain, in order to carry out our delicate mission, asked Rizal to explain his ideas about religion. He showed at once that he was a Protestant by certain phrases in which he manifested love and respect for Jesus Christ; but he told me more or less explicitly that the rule of faith was the word of God contained in the Sacred Scriptures; . . He told me that he was guided by the reason which God had given him, adding with a self assurance that froze the blood, that he could go to appear before the judgment seat of God, tranquilly as one who has done his duty as a rational man. In attacking him, I then began with arguments of the Catholic doctrine to expose the objections, a thousand times refuted, of the heretics and rationalists, and we argued about the criteria and rule of faith, the authority of the church, its infallibility and divine authority. . . nd many points in ap ologetics. But with all this, says Father Pio Pi, the poor condemned man was not convinced. So far had he lost his faith, and so proud was his self-conceit that he would not admit light nor law into his limited vision. . . With very good tact Father Balaguer tried him out, and giving a sudden turn in the conversation, exclaimed: (14) So, at the judgment seat of God, before whom we must appear, you will be unpardonably condemned forever, if you do not bring your intellect into subjection to faith. Whereupon, says Father Balauger, (15) at hearing this threat of mine, the tears sprang to his eyes, and he replied, No, no, I will not be condemned! Yes, I replied, you will go to hell; for whether you like it or not, extra Ecclesiam Catholicam nulla datur salus. Yes, outside the Catholic Church there is no salvation . . . Agitated at this chiding, he said to me: See here, Father, if I should comply with your request and sign what you propose, without feeling it, I would be a hypocrite and would offend God. Certainly, I said, I do not desire that. But do you not believe that it is the greatest grief for me to see a person whom I love, obstinate in his error, to see that he will be damned and not to be able to help him? We value you so highly, believe me, that we would give our blood and our lives if we could achieve your salvation. Right now we would offer ourselves to be shot in your place. But Father, he replied with feeling. What would you have me do, for I do not think I could conquer my reason. Offer yourself, I answered. Offer to God the sacrifice of your self-esteem, and even though it should be contrary to the voice of reason, ask God for the grace of faith, which is a gift of God, which he offers in abundance, and which is infallibly obtained with humble and persevering prayer. The only trouble is that you reject it. Good then, Father, he said, I promise you that the rest of my life I will use asking God for the grace of faith. . . . Father Balaguer continues: For a better understanding of the events of that day, I think it best to relate them in order. Father Vilaclara (now dead) and I arrived at Fort Santiago about ten in the morning. After being received by Rizal, the discussion with him began as related above. At twelve I went to the Palace to tell the Archbishop what had happened, as he had requested, and I had to say that up to that time the condemned man had remained obstinate in his errors and ideas contrary to the Catholic faith. Upon hearing this, the Archbishop, in his ardent zeal for the conversion of Dr. Rizal, at once sent a circular to all the religious communities of Manila, that they should plead for the conversion of the condemned man. In all of them there was fervent prayer, and in some of them there were offered for this purpose many penances, celebrating the Holy Sacrament. At three in the afternoon or a little later I returned to the Fort where Father Vilaclara had remained, and continued the discussion with Dr. Rizal. This lasted until evening, stopping at the point which I indicated above. I then went with Father Viza to the [Archbishops] palace, to give an account of the condition of the condemned man and to express hope for his conversion. While Father Balaguer was gone, Father Pio Pis account tells us that Rizal became restless and asked Father Vilaclara to hear his confession. The later told him that it would be necessary first to make a retraction, for which purpose he should await the formula which the Prelate had promised to furnish. . . At ten in the evening he was given [by Father Balaguer] the long formula of retraction which had been written by order of the Prelate. . . The inner fight had not yet ceased, and though his spirit was more humble, it was not wholly conquered. . . The wording did not suit him, both because of its length and because the style was not clear. See here, Father, he said, even though I should sign this, nobody would believe that it was mine. You know my style, that it is very clear. Bring me a pen and you dictate what I ought to say. Then Father Balaguer began to dictate the other formula, which had already been approved by the Archbishop, much briefer, though expressive and decisive, which, after offering some objections, he accepted in its entirety, only asking to interject on his own initiative a few brief phrases, which only add expression and courage to the document.

Essay on Bravery in The Tempest -- Tempest essays

The Theme of Bravery in The Tempest   Ã‚  Ã‚   Bravery performs a very important role in The Tempest.   Different than a motif, the theme of bravery actually takes form in Shakespeare's play and develops the play itself.   However, like a motif, bravery is used intermittently throughout the play in different form and context.   It captures different meanings and performs different capacities erratically.   A denotative definition from the 15th century, according to the Merriam-Webster Collegiate Dictionary (10 ed.), portrays brave as meaning, "[from Old Italian and Spanish, meaning courageous, wild; probably from Latin, meaning barbarous]."   The dictionary then defines brave as "a.   having courage: dauntless b.   making fine show: colorful, c. excellent, splendid."  Ã‚  Ã‚   All of these distinct definitions find their capacity in The Tempest.   Prospero could be said to define bravery when speaking to Ariel when he likens Ariel's bravery to being "firm, so constant...coil would not infect his reason"(I.ii.299).   Ariel's spirit is courageous and wild for he takes on the powers that be in order for Prospero to enact his revenge on the usurping Duke of Milan.  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Let's look at another example of bravery.   Miranda likens the form of Ferdinand to bravery.   Her young, inexperienced eyes have not seen a young man basically rise out of the sea before.   What wonder and show this must be to her concept of courage and splendid which are all definitions of brave.   Prospero even infers that Miranda herself is "more braver"(I.ii.672), than Ferdinand.   I believe that his foundation for this belief lies in our definition of brave in the aforementioned dictionary from 1546, "to face or endure with courage."   Miranda has endured much in her... ...er, Prospero designates Ariel "brave" because of his uninfected "reason" (I.ii.299-301).   So let's review.   Brave is monster, abominable, womanly, unequaled, propagation, diligent, conscientious towards directions and reasonable. "Is it so brave..."(III.ii.153)?   Yes, and everything else.    Bibliography Primary Texts William Shakespeare, The Tempest, ed. Frank Kermode, with an introduction by Frank Kermode, (Arden, 1964) Montaigne, Selected Essays of Montaigne, trans. John Florio (1603) ed.Walter Kaiser, with an introduction by Walter Kaiser, (Riverside, 1964)    Secondary Texts Curt Breight, " 'Treason doth never prosper': The Tempest and the discourse of treason, Shakespeare Quarterly, 41, no.1, (1990) Eric Cheyfitz, The Poetics of Imperialism: Translation and Colonization from The Tempest to Tarzan, (Oxford University Press, 1991)

Manage Domiciliary Services Essay

As a healthcare provider we have to ensure we have the correct amount of staff as well as staff with the right skill set and qualifications on shift which meets the needs of the people we are supporting. We do this by implementing standards from the beginning which includes the recruitment process. Our recruitment is robust but is constantly changing to ensure potential new staff are people that is right to be in healthcare, someone can fail at any time of the recruitment process. Our recruitment process includes: 1. Telephone Interview 2. Face to face Interview 3. 2 Day mandatory Training 4. Induction and final interview 5. 12 weeks probation Indicators that a potential new member of staff can fail in our recruitment process: a. Not understanding the importance for a client to maintain their independence b. Not understanding the importance for a client’s dignity and respect c. Not understanding the importance of working over a 7 day period d. Not participating in activities in mandatory training e. Not completing the Common Induction Standards f. Not completing courses in the 12 week probation period g. Not meeting the levels of reliability set out All members of staff that do not have a NVQ 2 when starting with E-Spire Healthcare must complete the Common Induction Standards within the first 12 weeks of commencing work with the company, after this period they can then proceed with NVQ level 2, which is encouraged, we rely on our local college to provide this support. When a new member of staff starts with E-Spire Healthcare they must first complete induction and shadow shifts without senior staff, only once the senior member of staff has signed them off as competent will they commence their shifts with our clients. This way our senior is able to introduce the new member of staff to our clients but they also have a complete understanding of our client’s needs and what support they require. Depending on the complexity of our client’s needs will depend  on which member of staff works with our clients, for instance somebody who has mental health issues will not be asked to complete shifts with that particular client until they have completed the relevant training courses and completed shadow shifts and been signed off by the senior member of staff. There is no maximum number of shadow shifts that a new member of staff needs to complete, this will depend on the individual member of staff, their past work history, qualifications. Myself or the senior member of staff would of completed the necessary paperwork before the commencement of the package including the care plan the client’s needs, support, risk assessments, medication, and emotional support plans, this way we already have an idea of what type of member of staff will work well with each particular client, as I feel this is a two way process the client and the Support Worker must be able to work together so the client can be motivated to keep their independence but also the Support Worker to enjoy working with each individual client and know they are supporting in the correct way and making a difference in their day to day lives. We also at the paperwork stage will know how many members of staff are required for each shift. Consistency of care is an extremely important factor for us, not only for the client but also the support worker: For the client: 1. They will get to know the member of staff 2. They will be able to open up to them if they have any certain problems 3. They will know that the member of staff understands their needs 4. They will know that they won’t have to keep explaining how they like specific tasks like to be completed 5. There will be trust between the client and member of staff 6. Personal care tasks will hopefully not be seen as daunting as the same person is with them 7. Trust when it comes to supporting people with their medication For the Support Worker: 1. They will get to know the individual client 2. Will understand how they like tasks to be completed 3. They are confident with how to support individual clients 4. They understand what motivates each individual client And many more reasons. Each individual client has a series of risk assessments completed for the  commencement of support package. This will include, medication, mobility, feeding, personal care as well as the immediate environment that the support worker will be working in. Depending on the individual client will determine how many members of staff will be required. This can depend on their mobility, their mental health, support in the community. If we feel that a package requires a different amount of staff to what is stated from for instance the social worker, we will go back to them and state our findings, but a package will not start until we have the correct amount of staff on each shift, as we need to keep both the client and our staff safe from injury and harm as well as the community too. I have a completed risk assessment attached with this document all personal details have been removed. E-Spire Health care have clear recruitment guidelines in place which all office staff know and understand a nd all abide by. No member of staff can commence with any shadow and induction shifts until we have on file: 1. Phone Interview 2. Face to Face Interview 3. 2 Day Mandatory Training 4. Induction and Final Interview 5. DBS 6. 2 references 7. Staff Members folder signed off by either myself or the director Carl Boulton. We have a excel document which is kept up to date of any potential member of staff that has approached E-Spire Healthcare this way we can ensure that we are not bringing anybody on board that has already tried to get through the recruitment process already. We also have a flow chart so we can refer back at any time if we are ensure of the process. Within healthcare we are supporting clients within their homes or a residential setting, so our staffs reliability and time keeping is essential, however with this said we will always occur a percentage of lateness and sickness, although we do have a procedure to monitor this and we will speak to any member of staff that does not hit the E-Spire targets ( separate occasions of illness within a 6 week period and also the same for lateness), as a company we do need to be prepared for the unexpected and people can fall ill at any time, this is why we have senior staff that their day to day roles  are shadow and inductions, reviews but to also pick up shifts at any time, we also have a deputy manager who also is able to go out and do shifts at any time. If need be there is also myself to go out to do shifts, but the same procedure applies to us too we must of completed shadow shifts with each client we will be going to, this is why shadow shifts and inductions are so important. Every client is an individual and their needs can change at any time, this can include cancelling shifts due to unforeseen circumstances such as going to hospital, doctor’s appointments, holidays, day trips out. It is our job to ensure that they are able to participate in any activity they need to. Hospital admission for instance is we will keep their shift slot open until they are able to come home, I know how important it is that when someone is able to come home, that they just want to come home, I do not want to be the reason why they are not able to come home, again this is a reason why we have senior staff available this way we can support clients with their task that is important to them. At E-Spire Healthcare and more importantly for myself I don’t want to meet CQC guidelines I want to exceed them, I am not in care to just give everyone the basic needs, I want to be able to provide support for people that is going to enhance their lives, maintain their independence, be emotionally supportive, and support them with the tasks that they need support with. Everything I do I also ask the same question â€Å"is this the type of support that is exceeds my expectations for my parents?† we monitor this by reviewing our clients care plans, speaking to them to see if they have any comments or complaints, asking them to complete questionnaires, which allows us to compile reports to see as a company where we can improve, because I feel we can always improve, if you’re not improving you’re not listening to people. We also complete a 12 week supervision for new members of staff, this goes towards their probationary period, this is a two way meeting with myself and the member of staff to both discuss the progress of the member of staff, it also gives the member of staff to give their opinion on subjects such as training, the clients their progress their needs. It is a document that will remain in each individual’s folder and it is a document that we are both able to refer back to, it includes: The member of staff role and responsibilities How the member of staff is meeting the company’s objectives and targets Any other training the member of staff feels they need to do Any problems the member of staff may have.  We then complete a target list of training and objectives for the member of staff to complete in the next 6 months, the next supervision would then not be with me as if the member of staff had an issue with myself they would then have the chance to discuss this with another member of staff. I feel this is a fair way to conduct supervisions, as the member of staff may feel more comfortable speaking to another member of the office team, but this way we are still able to improve for everyone. I am so the trainer for E-Spire healthcare but we also use other companies that are open to us which includes: 1. Local Colleges 2. Local District Nurses 3. The local authority I have attached my mandatory training course topics which indicates what is covered over the two days. To prepare myself for the training course I use a multitude of sources which are available to me, so I am fully informed so my information is up to date and informs and skills each individual member of staff so they have the knowledge to be practicable and skilful within their job role. I use: 1. British Red Cross 2. Trainer Courses (completed moving and handling and medication training) 3. CQC 4. Shropshire County Council 5. HSE Website 6. Food.gov.uk 7. You Tube 8. Speaking to clients 9. Personal experiences 10. Fire safe 11. Old Newspaper articles 12. SPIC 13. UK National Statistics

Srk N His Life

Shahrukh Khan From Wikipedia, the free encyclopedia Jump to: navigation, search â€Å"Shahrukh† redirects here. For the Timurid dynasty ruler, see Shah Rukh (Timurid dynasty). This article is semi-protected to prevent libelous additions. Shahrukh Khan Born 2 November 1965 (1965-11-02) (age 44) New Delhi, India Other name(s) Shah Rukh Khan, King Khan, SRK, King of Bollywood[1] Occupation Actor, producer, television presenter Years active 1988–present Spouse(s) Gauri Khan (1991–present) Shahrukh Khan (Hindi: , Urdu: ; born 2 November 1965), sometimes credited as Shah Rukh Khan, is an Indian actor and a prominent Bollywood figure, as well as a film producer and television host. Khan began his career appearing in several television serials in the late 1980s. He made his film debut in Deewana (1992). Since then, he has been part of numerous commercially successful films and has earned critical acclaim for many of his performances. Khan has won thirteen Filmfare A wards for his work in Indian films, seven of which are in the Best Actor category. Khan's films such as Dilwale Dulhaniya Le Jayenge (1995), Kuch Kuch Hota Hai (1998), Chak De India (2007), Om Shanti Om (2007) and Rab Ne Bana Di Jodi (2008) remain some of Bollywood's biggest hits, while films like Kabhi Khushi Kabhie Gham (2001), Kal Ho Naa Ho (2003), Veer-Zaara (2004) and Kabhi Alvida Naa Kehna (2006) have been top-grossing Indian productions in the overseas markets, making him one of the most successful actors of India. [2] Since 2000, Khan branched out into film production and television presenting as well. He is the founder/owner of two production companies, Dreamz Unlimited and Red Chillies Entertainment. In 2008, Newsweek named him one of the 50 most powerful people in the world. [3] Contents [hide] * 1 Biography * 2 Film career o 2. 1 Background o 2. 2 1990s o 2. 3 2000s * 3 Producer * 4 Television host * 5 Awards and nominations * 6 Filmography o 6. 1 Actor o 6. 2 Producer o 6. 3 Playback singer o 6. 4 Stunts director o 6. 5 Television appearances * 7 See also * 8 Bibliography * 9 Notes * 10 External links Biography Shahrukh Khan and family Khan was born in 1965 to Muslim parents of Pathan descent in New Delhi, India. [4] His father, Taj Mohammed Khan, was an Indian independence activist from Peshawar, British India. According to Khan, his paternal grandfather was originally from Afghanistan. [5] His mother, Lateef Fatima, was the adopted daughter of Major General Shah Nawaz Khan of the Janjua Rajput clan, who served as a General in the Indian National Army of Subash Chandra Bose. [6] Khan's father came to New Delhi from Qissa Khawani Bazaar in Peshawar before the partition of India,[7] while his mother's family came from Rawalpindi, British India. [8] Khan has an elder sister named Shehnaz. [9] Growing up in Rajendra Nagar neighbourhood,[10] Khan attended St. Columba's School where he was accomplished in sports, drama, and academics. He won the Sword of Honour, an annual award given to the student who best represents the spirit of the school. Khan later attended the Hansraj College (1985–1988) and earned his Bachelors degree in Economics (honors). Though he pursued a Masters Degree in Mass Communications at Jamia Millia Islamia, he later opted out to make his career in Bollywood. [11] After the death of his parents, Khan moved to Mumbai in 1991. [12] In that same year, before any of his films were released, he married Gauri Chibber, a Hindu, in a traditional Hindu wedding ceremony on 25 October 1991. 13] They have two children, son Aryan (b. 1997) and daughter Suhana (b. 2000). According to Khan, while he strongly believes in Allah, he also values his wife's religion. At home, his children follow both religions, with the Qur'an being situated next to the Hindu gods. [14] In 2005, Nasreen Munni Kabir produced a two-part documentary on Khan, titled The Inner and Outer World of Shah Rukh Khan. Featuring his 2 004 Temptations concert tour, the film contrasted Khan's inner world of family and daily life with the outer world of his work. The book Still Reading Khan, which details his family life, was released in 2006. Another book by Anupama Chopra, â€Å"King of Bollywood: Shahrukh Khan and the seductive world of Indian cinema†, was released in 2007. This book described the world of Bollywood through Khan's life. [15][16] Khan has been awarded several honours which includes the Padma Shri, India's fourth highest civilian award from the Government of India in 2005. In April 2007, a life-size wax statue of Khan was installed at the Madame Tussauds Wax Museum, London. Another statue was installed at the Musee Grevin in Paris, the same year. 17] During the same year, he was accorded the Ordre des Arts et des Lettres (Order of the Arts and Literature) award by the French government for his â€Å"exceptional career†. [18] In October 2008, Khan was conferred the Darjah Mulia Seri Melaka which carries the honorific Datuk (in similar fashion to â€Å"Sir† in British knighthood), by the Yang di-Pertua Neg eri Tun Mohd Khalil Yaakob, the head of state of Malacca in Malaysia. Khan was honoured for â€Å"promoting tourism in Malacca† by filming One Two Ka Four there in 2001. Some were critical of this decision. 19] He was also honoured with an honorary doctorate in arts and culture from Britain's University of Bedfordshire in 2009. [20] Film career Background Khan studied acting under celebrated Theatre Director Barry John at Delhi's Theatre Action Group (TAG). In 2007, John commented thus on his former pupil that, â€Å"The credit for the phenomenally successful development and management of Shahrukh's career goes to the superstar himself. â€Å"[21] Khan made his acting debut in 1988 when he appeared in the television series, Fauji, playing the role of Commando Abhimanyu Rai. 22] He went on to appear in several other television serials, most notably in the 1989 serial, Aziz Mirza's Circus, which depicted the life of circus performers. [23] The same year, Khan also had a minor role in the made-for-television English-language film, In Which Annie Gives it Those Ones, which was based on life at Delhi University and was written by Arundhati Roy. 1990s Upon moving from New Delhi to Mumbai in 1991,[24] Khan made his Bollywood movie debut in Deewana (1992). The movie became a box office hit, and launched his career in Bollywood. [25] His performance won him a Filmfare Best Male Debut Award. He went on to star in Maya Memsaab, which generated some controversy because of his appearance in an â€Å"explicit† sex scene in the movie. [26] In 1993, Khan won acclaim for his performances in villainous roles as an obsessive lover and a murderer, respectively, in the box office hits, Darr and Baazigar. [27] Darr marked his first collaboration with renowned film-maker Yash Chopra and his banner Yash Raj Films, the largest production company in Bollywood. Baazigar, which saw Khan portraying an ambiguous avenger who murders his girlfriend, shocked its Indian audience with an unexpected violation of the standard Bollywood formula. 28] His performance won him his first Filmfare Best Actor Award. In that same year, Khan played the role of a young musician in Kundan Shah's Kabhi Haan Kabhi Naa, a performance that earned him a Filmfare Critics Award for Best Performance. Khan maintains that this is his all-time favourite among the movies he has acted in. [29] In 1994, Khan once ag ain played an obsessive lover/psycho's role in Anjaam, co-starring alongside Madhuri Dixit. Though the movie was not a box office success, Khan's performance earned him the Filmfare Best Villain Award. [30] In 1995, Khan starred in Aditya Chopra's directorial debut Dilwale Dulhania Le Jayenge, a major critical and commercial success, for which he won his second Filmfare Best Actor Award. [31] In 2007, the film entered its twelfth year in Mumbai theaters. By then the movie had grossed over 12 billion rupees, making it as one of India's biggest movie blockbusters. [32] Earlier in the same year he found success in Rakesh Roshan's Karan Arjun which became the second biggest hit of the year. 1996 was a disappointing year for Khan as all his movies released that year failed to do well at the box office. 33] This was, however, followed by a comeback in 1997. He saw success with Subhash Ghai's social drama Pardes — one of the biggest hits of the year — and Aziz Mirza's comedy Yes Boss, a moderately successful feature. [34] His second project with Yash Chopra as a director, Dil to Pagal Hai became that year's second highest-grossing movie, and he won his third Filmfare Best Actor A ward for his role as a stage director who falls in love with one of his new actresses. [34] In 1998, Khan starred in Karan Johar's directorial debut, Kuch Kuch Hota Hai, which was the biggest hit of the year. 35] His performance won him his fourth Best Actor award at the Filmfare. He won critical praise for his performance in Mani Ratnam's Dil Se. The movie did not do well at the Indian box office, though it was a commercial success overseas. [36] Khan's only release in 1999, Baadshah, was an average grosser. [37] 2000s Khan's success continued with Aditya Chopra's 2000 film, Mohabbatein, co-starring Amitabh Bachchan. It did well at the box office, and Khan's performance as a college teacher won him his second Critics Award for Best Performance. He also starred in Mansoor Khan's action film Josh. The film starred Khan as the leader of a Christian gang in Goa and Aishwarya Rai as his twin sister, and was also a box office success. [38] In that same year, Khan set up his own production house, Dreamz Unlimited with Juhi Chawla (see below). Both Khan and Chawla starred in the first movie of their production house, Phir Bhi Dil Hai Hindustani. [38] His work with Karan Johar continued as he collaborated on the family drama Kabhi Khushi Kabhie Gham which was the second biggest hit of the year. He also received favorable reviews for his performance as Emperor Asoka in the historical epic, Asoka, a partly fictionalised account of the life of Ashoka the Great (304 BC–232 BC). [39] In 2002, Khan received acclaim for playing the title role in Sanjay Leela Bhansali's award-winning period romance, Devdas. It was the third Hindi movie adaptation of Sharat Chandra Chattopadhyay's well-known novel of the same name, and surfaced as one of the biggest hits of that year. [40] Khan also starred opposite Salman Khan and Madhuri Dixit in the family-drama Hum Tumhare Hain Sanam, which did well at the box office. 40] In 2003, Khan starred in the moderately successful romantic drama, Chalte Chalte. [41] That same year, he starred in the tearjerker, Kal Ho Naa Ho, written by Karan Johar and directed by Nikhil Advani. Khan's performance in this movie as a man with a fatal heart disease was appreciated. The movie proved to be one of the year's biggest hits in India and Bollywood's bigges t hit in the overseas markets. [41] 2004 was a particularly good year for Khan, both commercially and critically. He starred in Farah Khan's directorial debut, the comedy Main Hoon Na. The movie did well at the box office. He then played the role of an Indian officer, Veer Pratap Singh in Yash Chopra's love saga Veer-Zaara, which was the biggest hit of 2004 in both India and overseas. [42] The film relates the love story of Veer and Pakistani woman Zaara Haayat Khan, played by Preity Zinta. Khan's performance in the film won him awards at several award ceremonies. In that same year, he received critical acclaim for his performance in Ashutosh Gowariker's drama Swades. He was nominated for the Filmfare Best Actor Award for all three of his releases in 2004, winning it for Swades. [42] In 2006, Khan collaborated with Karan Johar for the fourth time with the melodrama movie Kabhi Alvida Na Kehna. It did well in India and much more so in the overseas market, becoming the biggest Bollywood hit in the overseas market of all-time. [43] His second release that year saw him playing the title role in the action film Don, a remake of the 1978 hit Don. The movie was a success. [43] Khan's success continued with a few more highly popular films. One of his most successful works was the multiple award-winning 2007 film, Chak De India, about the Indian women's national hockey team. Earning over Rs 639 million, Chak De India became the third highest grossing movie of 2007 in India and won yet another Filmfare Best Actor Award for Khan. [44] The film was a major critical success. [45] In the same year Khan also starred in Farah Khan's 2007 film, Om Shanti Om. The film emerged as the year's highest grossing film in India and the overseas market, and became India's highest grossing production ever up to that point. [44] It earned him another nomination for Best Actor at the Filmfare ceremony. Khan's more recent films include the 2008 release, Rab Ne Bana Di Jodi which was a huge box office success, and Billu. Khan's next film, My Name Is Khan, is due for release on 12 February 2010. While on one shoot in Los Angeles, along with his wife Gauri and director Karan Johar, he took a break from filming to attend the 66th Golden Globe Awards, held in Los Angeles, California, on 11 January 2009. [46][47] Khan introduced Slumdog Millionaire along with a star from the film, Freida Pinto. [48][49] Producer Khan turned producer when he set up a production company called Dreamz Unlimited with Juhi Chawla and director Aziz Mirza in 1999. The first two of the films he produced and starred in: Phir Bhi Dil Hai Hindustani (2000) and Asoka (2001) were box office failures. [39] However, his third film as a producer and star, Chalte Chalte (2003), proved a box office hit. [41] In 2004, Khan set up another production company, Red Chillies Entertainment, and produced and starred in Main Hoon Na, another hit. [42] The following year, he produced and starred in the fantasy film Paheli, which did poorly. [50] It was, however, India's official entry to the Academy Awards for consideration for Best Foreign Language Film, but it did not pass the final selection. Also in 2005, Khan co-produced the supernatural horror film Kaal with Karan Johar, and performed an item number for the film with Malaika Arora Khan. Kaal was moderately successful at the box office. [50] His company has gone on to produce Om Shanti Om (2007), in which he starred, and Billu (2009), in which he played a supporting role as a Bollywood superstar. Apart from film production, the company also has a visual effects studio known as Red Chillies VFX. It has also ventured into television content production, with shows like, The First Ladies, Ghar Ki Baat Hai', and Knights and Angels. Television advertisements are also produced by the company. [51] In 2008, Red Chillies Entertainment became the owner of the Kolkata Knight Riders in the BCCI-backed IPL cricket competition. Television host In 2007, Khan replaced Amitabh Bachchan as the host of the third series of the popular game show Kaun Banega Crorepati, the Indian version of Who Wants to Be a Millionaire?. [52] The previous had hosted the show for five years from 2000–05. On 22 January 2007, Kaun Banega Crorepati aired with Khan as the new host[53] and later ended on 19 April 2007. [54] On 25 April 2008, Khan began hosting the game show Kya Aap Paanchvi Pass Se Tez Hain? , the Indian version of Are You Smarter Than a 5th Grader? ,[55] whose last episode was telecasted on 27 July 2008, with Lalu Prasad Yadav as the special guest. [56] Awards and nominations Main article: List of Shahrukh Khan's awards and nominations Filmography Actor Year Title Role Notes 1992 Deewana Raja Sahai Winner, Filmfare Best Male Debut Award Idiot Pawan Raghujan Chamatkar Sunder Srivastava Raju Ban Gaya Gentleman Raju (Raj Mathur) Dil Aashna Hai Karan 1993 Maya Memsaab Lalit Kumar King Uncle Anil Bhansal Baazigar Ajay Sharma/Vicky Malhotra Winner, Filmfare Best Actor Award Darr Rahul Mehra Nominated, Filmfare Best Villain Award Kabhi Haan Kabhi Naa Sunil Winner, Filmfare Critics Award for Best Performance Nominated, Filmfare Best Actor Award 1994 Anjaam Vijay Agnihotri Winner, Filmfare Best Villain Award 1995 Karan Arjun Arjun Singh/Vijay Zamana Deewana Rahul Malhotra Guddu Guddu Bahadur Oh Darling! Yeh Hai India Hero Dilwale Dulhania Le Jayenge Raj Malhotra Winner, Filmfare Best Actor Award Ram Jaane Ram Jaane Trimurti Romi Singh 1996 English Babu Desi Mem Vikram/Hari/Gopal Mayur Chaahat Roop Rathore Army Arjun Special appearance Dushman Duniya Ka Badru 1997 Gudgudee Special appearance Koyla Shankar Yes Boss Rahul Joshi Nominated, Filmfare Best Actor Award Pardes Arjun Saagar Dil To Pagal Hai Rahul Winner, Filmfare Best Actor Award 1998 Duplicate Bablu Chaudhry/Manu Dada Nominated, Filmfare Best Villain Award Achanak Himself Special appearance Dil Se Amarkant Varma Kuch Kuch Hota Hai Rahul Khanna Winner, Filmfare Best Actor Award 1999 Baadshah Raj Heera/Baadshah Nominated, Filmfare Best Comedian Award 2000 Phir Bhi Dil Hai Hindustani Ajay Bakshi Hey Ram Amjad Ali Khan Josh Max Har Dil Jo Pyar Karega Rahul Special appearance Mohabbatein Raj Aryan Malhotra Winner, Filmfare Critics Award for Best Performance Nominated, Filmfare Best Actor Award Gaja Gamini Himself Special appearance 2001 One 2 Ka 4 Arun Verma Asoka Asoka Kabhi Khushi Kabhie Gham Rahul Raichand Nominated, Filmfare Best Actor Award 2002 Hum Tumhare Hain Sanam Gopal Devdas Devdas Mukherjee Winner, Filmfare Best Actor Award Shakti: The Power Jaisingh Special appearance Saathiya Yeshwant Rao Cameo 2003 Chalte Chalte Raj Mathur Kal Ho Naa Ho Aman Mathur Nominated, Filmfare Best Actor Award 2004 Yeh Lamhe Judaai Ke Dushant Main Hoon Na Maj. Ram Prasad Sharma Nominated, Filmfare Best Actor Award Veer-Zaara Veer Pratap Singh Nominated, Filmfare Best Actor Award Swades Mohan Bhargava Winner, Filmfare Best Actor Award 2005 Kuch Meetha Ho Jaaye Himself Special appearance Kaal Special appearance in song Kaal Dhamaal Silsiilay Sutradhar Special appearance in song Jab Jab Dil Mile Paheli Kishenlal/The Ghost The Inner and Outer World of Shah Rukh Khan Himself (Biopic) Documentary directed by British-based author and director Nasreen Munni Kabir 2006 Alag Special appearance in song Sabse Alag Kabhi Alvida Naa Kehna Dev Saran Nominated, Filmfare Best Actor Award Don – The Chase Begins Again Vijay/Don Nominated, Filmfare Best Actor Award Nominated, Asian Film Award for Best Actor I See You Special appearance in song Subah Subah 2007 Chak De India Kabir Khan Winner, Filmfare Best Actor Award Heyy Babyy Raj Malhotra Special appearance in song Mast Kalandar Om Shanti Om Om Prakash Makhija/Om Kapoor Nominated, Filmfare Best Actor Award 2008 Krazzy 4 Special appearance in song Break Free Bhoothnath Aditya Sharma Special appearance Rab Ne Bana Di Jodi Surinder Sahni/Raj Nominated, Filmfare Best Actor Award 009 Luck by Chance Himself Special appearance Billu Sahir Khan Aao Wish Karein Narrator [57] 2010 Dulha Mil Gaya Released on 8 January 2010 My Name Is Khan Rizwan Khan Releasing on 12 February 2010 Ra. 1 Koochie Koochie Hota Hain Rocky Filming Producer * Phir Bhi Dil Hai Hindustani (2000) * Asoka (2001) * Chalte Chalte (2003) * Main Hoon Na (2004) * Kaal (2005) * Paheli (2005) * Om Shanti Om (2007) * Billu (2009) Playback singer * Main to hoon Pagal – Baadshah (1999) * Apun Bola – Josh (2000) * Khaike Paan Banaraswala – Don – The Chase Begins Again (2006) * Ek Hockey Doongi Rakhke – Chak De India (2007) Sattar Minute – Chak De India (2007) Stunts director * Kuch Kuch Hota Hai (1998) * Main Hoon Na (2004) * Kabhi Alvida Naa Kehna (2006) * Chak De India (2007) * Om Shanti Om (2007) Television appearances * Dil Dariya (1988) * Fauji (1988) †¦ Abhimanyu Rai * Doosra Keval (1989) * Circus (1989) * In Which Annie Gives It Those Ones (1989) * Idiot (1991) †¦ Pawan Raghujan * Kareena Kareena (2004) †¦ Special appearance * Rendezvous with Simi Garewal†¦.. Guest * Koffee with Karan (2004–2007) †¦ Guest (3 episodes) * Kaun Banega Crorepati (2007) †¦ Host * Jjhoom India (2007) †¦ Guest * Nach Baliye (2008) †¦. Guest * Kya Aap Paanchvi Pass Se Tez Hain? (2008) †¦. Host * Oye! It's Friday! (2009) †¦ Guest * Tere Mere Beach Mein (2009) †¦ Guest See also * List of Indian Actors * Newark Airport Incident Bibliography * Nasreen Munni Kabir. The Inner and Outer World of Shah Rukh Khan (Documentary, 2005). * Shahrukh Khan – Still Reading Khan. A1Books Distributor 2007. ISBN 9788187107798. * Gahlot, Deepa; Agarwal, Amit. King Khan SRK. Augsburg Weltbild 2007. ISBN 9783828988699. * Ghosh, Biswadeep. Hall of fame: Shahrukh Khan (in English). Mumbai: Magna Books, 2004. ISBN 8178092379. * Chopra, Anupama. King of Bollywood : Shah Rukh Khan and the seductive world of Indian cinema (English). New York: Warner Books, 2007. ISBN 9780446578585. Notes 1. ^ â€Å"Indian cinema doing well because of cultural ethos: Shah Rukh Khan†. The Hindu. 17 June 2007. http://www. hindu. com/thehindu/holnus/009200706171961. htm. Retrieved 2009-08-16. 2. ^ Kumar, Anuj (11 November 2004). â€Å"Bollywood bonanza†. The Hindu. http://www. hindu. com/mp/2004/11/11/stories/2004111101010300. htm. Retrieved 2009-08-16. Kamath, Sudhish (7 December 2007). Being SRK†. The Hindu. http://www. hindu. com/cp/2007/12/07/stories/2007120750010100. htm. Retrieved 16 August 2009. 3. ^ â€Å"The Global Elite – 41: Shahrukh Khan†. Newsweek. 20 December 2008. http://www. newsweek. com/id/176325. Retrieved 24 December 2008. 4. ^ â€Å"The Rediff Interview / Shah Rukh Khan†. Rediff. http://www. rediff. com/movies/2007/mar/16srk . htm. Retrieved 5 July 2006. 5. ^ 2009 interview with an Afghan movie director on Afghan TV channel, Shahrukh Khan states that his father's father (grandfather) is from Afghanistan. 6. ^ â€Å"Badshah at durbar and dinner†. elegraphindia. com. http://www. telegraphindia. com/1040531/asp/frontpage/story_3313328. asp. Retrieved 12 March 2007. 7. ^ â€Å"Rediff News Gallery: The Shahrukh Connection†. http://specials. rediff. com/news/2004/may/31sl02. htm. 8. ^ A Hundred Horizons by Sugata Bose, 2006 USA, p136 9. ^ â€Å"Shahrukh Khan – Journey†. http://movies. indiatimes. com/cms. dll/articleshow? artid=177008&right=1&fright=1&botlink=1. 10. ^ SRK to run for Delhi TNN, The Times of India, 30 September 2009. â€Å"I was born here, in Talwar Nursing Home. I lived here for more than two decades in Rajinder Nagar† 11. IndiaFM News Bureau (2 November 2006). â€Å"Facts you never knew about SRK†. indiaFM. http://www. indiafm. com/features/2006/11/02 /1777. Retrieved 26 July 2008. 12. ^ â€Å"Shah Rukh Khan turns 42†. zeenews. com. http://www. zeenews. com/znnew/articles. asp? aid=404915&sid=ZNS&sname=exclusive-news. Retrieved 2 November 2007. 13. ^ Siddiqui, Rana (17 November 2006). â€Å"Much ado about King Khan†. The Hindu. http://www. hinduonnet. com/thehindu/fr/2006/11/17/stories/2006111701130100. htm. Retrieved 9 February 2008. 14. ^ Zubair Ahmed (23 September 2005). â€Å"Who's the real Shah Rukh Khan? â€Å". BBC News – BBC.

Ketamine Abused Drug or Medical Miracle Professor Ramos Blog

Ketamine Abused Drug or Medical Miracle Ketamine: Abused Drug or Medical Miracle When the synthetic drug Ketamine first was synthesized it was mainly used on animals as an anesthetic. The reason it is used on animals is that it was found to have hallucinogenic effects on humans. Today ketamine is mainly used on humans by medical teams in small doses as an anesthetic, however it does have other uses in the medical field. As with many other synthetic drugs that can cause hallucinations, it has become popular for recreational use. I have seen ketamine used in different settings and I can’t help but wonder. Can Ketamine be used in a medical setting? When ketamine is abused what does do to the brain? How Ketamine Was Created Ketamine was synthesized from a chemical compound known as phencyclidine, this compound was previously tested on humans to treat schizophrenia. After more clinical studies â€Å"it became clear that phencyclidine was not suitable for human anesthesia† (Domino 679), because it caused hallucinations. Cal Bratton, M.D., Ph.D., Head of Pharmaceutical Research at Parke Davis stated that he â€Å"was convinced that a short-acting derivative would be useful† (Domino 679). Bratton consulted Calvin Lee Stevens on the matter after discussing with each other they decided to synthesize derivatives of phencyclidine. One of these compounds was known as CI-581, this compound was later named Ketamine. Trials on animals went well and soon began trials on humans. It was observed during human testing that ketamine worked extremely well for anesthesia and with little to no side effects. Edward F. Domino, M.D. helped with clinical trials of ketamine, after much research he and his colleague s decided it was time to publish their findings. â€Å"I mentioned that the subjects were â€Å"disconnected† from their environment. Toni came up with the term â€Å"dissociative anesthetic† (Domino 680). Ketamine is known as a dissociative anesthetic, this means that the user is generally â€Å"not all there† when they return from the anesthetic state. Today, the world knows ketamine as a medication that vets use on animals to put them to sleep for surgeries. As you can see the scientist who created ketamine had a completely different use in mind. They were searching for a cure to schizophrenia, they never imagined what it would become today. Medical Uses of Ketamine Ketamine research for various mental disorders has been done extensively. In almost all these cases it has shown that Ketamine has a profound effect on the brain when administered properly. The main mental disorder ketamine has been used to treat is depression. Research has demonstrated â€Å"improvement in 12 of 15 depressed patients (79%), which was maintained for 14 days† (Kraus, 7). Overall when used to treat depression ketamine shown very promising signs, â€Å"clinical trials demonstrate that †¦ ketamine is highly effective and rapid acting† (Kraus, 8). Kraus states that â€Å"in comparison with other treatments †¦ ketamine is less invasive †¦ ketamine does not need supervision by an anesthetist and can be performed in a controlled outpatient setting† (9). Ketamine can also be used to treat severe pain. The following information is based off findings from various hospital emergency departments. These hospitals include Alameda Health System, Highland Hospital and some research done at University of California, San Francisco, California. Terence L Ahern MD states that in his studies of ketamine for pain â€Å"38 patients were included with a median initial numerical rating scale pain score 9 of 10. At 10 minutes, the median reduction in pain score was 4† (1402). (see table 1). Table 1 This table shows pain rating of Emergancy Room patients from initial to 10 minutes to 60 minutes of treatment Source: Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain: Pain Medicine, vol. 16, no. 7, July 2015, table 1. The ketamine was administered via IV most of the people who used it as a pain treatment were asked; â€Å"Would you have this medication again for similar pain? †¦ (84%) responded they would have ketamine again† (Ahern 1403-1404). As with all drugs ketamine does have side effects. The more common side effects are dizziness, blurred vision, nausea and poor concentration (see fig. 1). Fig. 1. Side effects of ketamine administration on infusion day and post infusion in percent from Murrough et al.; â€Å"Administration of ketamine for unipolar and bipolar depression†; International Journal of Psychiatry in Clinical Practice; pp. 7. As you can see from the chart above, the side effects are mild and uncommon. From my research I have learned that Ketamine can be extremely beneficial if used properly. It has effects on the brain and the body in positive ways, without major and long lasted side effects. Recreational Use and Effects of Ketamine Ketamine has a very large spike in recreational use recently due to the rise of club and rave cultures. Use is ketamine varies widely from person to person. Infrequent users generally use it while going to clubs, raves and other parties. Frequent users say they use it daily in ranges of one half to 3 grams. When someone is on ketamine the user feels disassociated from the world. I’ve have seen people on large dosages of ketamine (1-3grams) from what I can see the person would seem very confused on to what was going on around him. He could not hold a conversation, let alone a thought for more then a few seconds. The user would periodically â€Å"come back to reality† and be fully conscious, but this would last a max of 20 seconds. They would suddenly drift back into their disassociated state. After about 20 minutes they would be fully conscious again and able to hold conversation, but still slightly in their ketamine high. They would talk slow and slur their words. The brain is heavily affected by prolonged ketamine use, in most cases it destroys multiple regions of the brain. According to Chunmei Wang of the Brain Research Center, Institute of Chinese Medicine â€Å"the brain regions affected were prefrontal, parietal, occipital, limbic, brainstem and corpus striatum. The lesions affected both the gray and white matter† (5). (see fig. 2). Fig. 2.   The left shows a normal brain with no drug abuse. The right is an addicts’ brain who has done a half gram of ketamine each day for seven years. You can see that some sections of the brain almost looked smashed or caved in, this is where it has deteriorated from the usage of ketamine from Chunmei Wang et al.; â€Å"Brain damages in ketamine addicts as revealed by magnetic resonance imaging†; Frontiers in Neuroanatomy, vol. 7, no. 23, 2013; pp. 1-6 According to the report In and out of the K-hole: a comparison of the acute and residual effects of ketamine in frequent and infrequent ketamine users ketamine has a major effect on cognitive ability when abused. The research in this article includes different assessments that test areas of cognitive ability, there was a total of 37 participants. 18 of them were frequent users and 19 were infrequent. The assessment was done on the day of the usage and 3 days later. In all cases those who used ketamine frequently (about 20 times a month) scored much lower on the test then those who used it infrequently (once every two months). These assessments tested areas such as memory, speed of comprehension and verbal fluency. The memory assessment showed that â€Å"following an acute dose both groups scored similarly; however, on day 3, frequent users were still highly impaired† (Curran and Monaghan, 754). For the speed of comprehension assessment Curran and Monaghan states â€Å"this ta sk, reflecting poorer performance on both test days by the frequent users† (755). The group of infrequent users performed much better on both days. Verbal Fluency, the last assessment showed similar results to the speed of comprehension test. These tests prove that frequently using ketamine will impact the user on a larger scale for much longer. Conclusion   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Ketamine can be used in a variety of ways both medical and recreational. There are great benefits to use ketamine in a medical setting and while having very little side effects. Ketamine can be used to treat mental disorders such as depression and be used to treat pain. However, ketamine can be abused in recreational settings. Therefore, ketamine is a schedule III drug in America, it has potential for abuse but still have medical use potential. Although it has medical uses ketamine is still illegal in the United States. When ketamine is abused, it damages the brain and causes severe cognitive disability. These negative effects are long lasting and in cases of the brain deterioration cannot be reversed. Ahern, Terence L., et al. â€Å"Low-Dose Ketamine Infusion for Emergency Department Patients with Severe Pain.† Pain Medicine, vol. 16, no. 7, July 2015, pp. 1402–1409. EBSCOhost, doi:10.1111/pme.12705. This article is based on a clinical research study of the use of ketamine for severe pain. In this study a total of 38 people were administered ketamine in small doses for various sources of pain. After 120 minutes the people were asked to rate their pain and if they would take it again. In most cases their pain was significantly lower, and 32 people said they would take it again for similar pain. I will use this in my report to show that ketamine can be used for more treatment of pain as well as depression. This is a very reliable source as the information is derived directly from test that were administered by the doctors who wrote the article. Domino, Edward F. â€Å"Taming the Ketamine Tiger.†Ã‚  Anesthesiology, 2010, pp. 678–680. This article explains how ketamine came to be. It teaches you that ketamine was derived from phencyclidine. Its purpose was to be used on humans for anesthesia, although today it is mostly used in veterinary clinics for that purpose. I am using this is my report to give a background on how ketamine came to be, I feel to understand this drug you need to know why it was created. The source is a first-hand experience from the man who created it, his name is Edward F. Domino M.D. PHD, was a Professor of Pharmacology at the University of Michigan for 50 years, in that time he has worked on many research projects with various chemical compounds. Curran, H.Valerie, and Lisa Monaghan. â€Å"In and out of the K-Hole: A Comparison of the Acute and Residual Effects of Ketamine in Frequent and Infrequent Ketamine Users.† Addiction, vol. 96, no. 5, May 2001, pp. 749–760. EBSCOhost, doi:10.1080/09652140020039116. This article is a study of recreational ketamine users. It studies the user’s ability to perform cognitive task before and after taking ketamine. They use several different tasks which target different areas of the brain. I plan to use this in my research to show the effects ketamine on the brain when doing normal everyday tasks. I find this research to be reliable as it comes from Psychopharmacology Research Unit, Sub-department of Clinical Health Psychology, University College London, London, UK. Kraus, Christoph, et al. â€Å"Administration of Ketamine for Unipolar and Bipolar Depression.† International Journal of Psychiatry in Clinical Practice, vol. 21, no. 1, Mar. 2017, pp. 2–12. EBSCOhost, doi:10.1080/13651501.2016.1254802. This article is based on a clinical research study of the uses in ketamine to treat mild to severe depression.   The research in the article contains a total of 19 clinical trials that all had positive results. I will be using this in my report to show the possible use of ketamine for treating depression which is considered a mental health disorder. This research was taken from the International Journal of Psychiatry in Clinical Practice, it was written by the people who conducted the clinical trials and is based directly on their findings. Wang Chunmei, et al. â€Å"Brain damages in ketamine addicts as revealed by magnetic resonance imaging† Frontiers in Neuroanatomy, vol. 7, no. 23, 2013, pp. 1-6, doi:10.3389/fnana.2013.00023. This article is based on a study of ketamine addicts in the range of 0.5 to 12 years of ketamine addiction at various dosage amounts. It focuses on brain imaging to study the users’ brain and how it has been affected by ketamine. I will use this in my research to show the negative effects ketamine has on the human brain. I find this to be a reliable source because it is research produced by the Brain Research Center, Institute of Chinese Medicine, The Chinese University of Hong Kong.

Mr See Essays

Mr See Essays Mr See Essay Mr See Essay 1) What is grammatically incorrect with the following sentence? What time are you two going to go out? Choose one answer. | |a) The infinitive â€Å"to go† should be split by an adverb. | | | |b) It ends with a preposition. | | | |C. )The phrasal verb â€Å"go out† is casual English and as such, it should only be used in speech, never in writing. | | | |d) There is nothing grammatically wrong with this sentence. | | 2) In the following sentence â€Å"running† is what part of speech? Running every day is great exercise! Choose one answer. | |a) a gerund | | | |b) a particle | | | |C. )a verb in the present progressive tense | | | |d) a verb in the perfect tense | | 3) Which of the following parts of speech should never be used to start a sentence? Choose one answer. | |a) a pronoun without an antecedent | | | |b) a preposition | | | |C. )a subordinating conjunction such as â€Å"because† or â€Å"although† | | | |D. Any part of speech can be used to start a sentence so long as the sentence has a subject and predicate and is appropriately structured | | | | | | 4) Which of the following is not a conditional sentence? Choose one answer. | |A. )I wont go unless you do. | | | |B. )Id have helped you if Id been around. | | | |c) She will pass, but only if she studies hard. | | | |D. Theyll meet us there after lunch | | | | | | 5) Which of the following is not true about the phrase ‘I had better’? Choose one answer. | |A. )It refers to the past. | | | |B. )It is used for giving strong advice. | | | |C. )It can be made negative. | | | |D. )It can be contracted | |

Alexander von Humboldt - Founder of Modern Geography

Alexander von Humboldt - Founder of Modern Geography Charles Darwin described him as the greatest scientific traveler who ever lived. He is widely respected as one of the founders of modern geography. Alexander von Humboldts travels, experiments, and knowledge transformed western science in the nineteenth century. Early Life Alexander von Humboldt was born in Berlin, Germany in 1769. His father, who was an army officer, died when he was nine years old so he and his older brother Wilhelm were raised by their cold and distant mother. Tutors provided their early education which was grounded in languages and mathematics. Once he was old enough, Alexander began to study at the Freiberg Academy of Mines under the famous geologist A.G. Werner. Von Humboldt met George Forester, Captain James Cooks scientific illustrator from his second voyage, and they hiked around Europe. In 1792, at the age of 22, von Humboldt began a job as a government mines inspector in Franconia, Prussia. When he was 27, Alexanders mother died, leaving him as substantial income from the estate. The following year, he left government service and began to plan travels with Aime Bonpland, a botanist. The pair went to Madrid and obtained special permission and passports from King Charles II to explore South America. Once they arrived in South America, Alexander von Humboldt and Bonpland studied the flora, fauna, and topography of the continent. In 1800 von Humboldt mapped over 1700 miles of the Orinco River. This was followed by a trip to the Andes and a climb of Mt. Chimborazo (in modern Ecuador), then believed to be the tallest mountain in the world. They didnt make it to the top due to a wall-like cliff but they did climb to over 18,000 feet in elevation. While on the west coast of South America, von Humboldt measured and discovered the Peruvian Current, which, over the objections of von Humboldt himself, is also known as the Humboldt Current. In 1803 they explored Mexico. Alexander von Humboldt was offered a position in the Mexican cabinet but he refused. Travels to America and Europe The pair were persuaded to visit Washington, D.C. by an American counselor and they did so. They stayed in Washington for three weeks and von Humboldt had many meetings with Thomas Jefferson and the two became good friends. Von Humboldt sailed to Paris in 1804 and wrote thirty volumes about his field studies. During his expeditions in the Americas and Europe, he recorded and reported on magnetic declination. He stayed in France for 23 years and met with many other intellectuals on a regular basis. Von Humboldts fortunes were ultimately exhausted because of his travels and self-publishing of his reports. In 1827, he returned to Berlin where he obtained a steady income by becoming the King of Prussias advisor. Von Humboldt was later invited to Russia by the tsar and after exploring the nation and describing discoveries such as permafrost, he recommended that Russia establish weather observatories across the country. The stations were established in 1835 and von Humboldt was able to use the data to develop the principle of continentality, that the interiors of continents have more extreme climates due to a lack of moderating influence from the ocean. He also developed the first isotherm map, containing lines of equal average temperatures. From 1827 to 1828, Alexander von Humboldt gave public lectures in Berlin. The lectures were so popular that new assembly halls had to be found due to the demand. As von Humboldt got older, he decided to write everything known about the earth. He called his work Kosmos and the first volume was published in 1845, when he was 76 years old. Kosmos was well written and well received. The first volume, a general overview of the universe, sold out in two months and was promptly translated into many languages. Other volumes focused on such topics as humans effort to describe the earth, astronomy, and earth and human interaction. Humboldt died in 1859 and the fifth and final volume was published in 1862, based on his notes for the work. Once von Humboldt died, no individual scholar could hope any longer to master the worlds knowledge about the earth. (Geoffrey J. Martin, and Preston E. James. All Possible Worlds: A History of Geographical Ideas., page 131). Von Humboldt was the last true master but one of the first to bring geography to the world.

Decomposition Framework for Financial Analysis. Kforce Inc. and Morson Essay

Decomposition Framework for Financial Analysis. Kforce Inc. and Morson Group Plc - Essay Example Moreover, the investors needed to determine the underlying value of these investments in order to make sure that prices are rightly placed before making any decision related to purchase. These investors are generally called as rational investors who conduct analytical studies before making any decision related to investments. In this regard, the security valuation and financial statement have become very important. Financial analyses are those financial tactics and methods which help in comparing and evaluating the different investment opportunities such as projects and firms, to ensure and evaluate that the available opportunities are appropriate for making investments. Generally, the procedure of conducting financial analysis is based upon the past performance of a firm. The historical data is then used to evaluate the future performance of the company; therefore it is not at all necessary that evaluations are 100% accurate. Financial analysts usually obtain data from a variety of sources available, including income statements, balance sheets, and cash flow statements. Through these financial statements, analysts determine the ability of a firm to meet its liabilities and obligations, stability of a firm, level of profitability and liquidity and then compare them with their competitors in order to provide insights into the firm’s position as compared to the industry or its competitors. In balance sheet, the underlying financial position of of a company is present. The three main categories of which balance sheet is comprised include: assets, which demonstrate the long term and current investments of a firm through which revenues are expected to be generated; liabilities depict the long term and short term claims that stakeholders have; and equity which demonstrates the claim of the owners. This paper aims to analyze a U.K company, namely Morson Group PLC, in comparison with a U.S based firm known as Kforce Inc. The analytical methods utilized in this paper for analysis include: common-size analysis, trend analysis and profitability analysis. Understanding the Industry Companies which want to improve their performance need to provide training to their staff in recruitment centers. Leaders also get training so as to motivate their workers and working with efficient employees. A real competition among organizations has taken place nowadays. Every other company is st riving hard to develop the skills of its employees. In this regard, a lot of training and development programs are being established every other day. Subsequently, a new type of competition between employees and management has also taken place. For this reason, companies are looking for recruitment companies so as to develop the special needs of their staff. Recruitment companies play a vital role in improving the facilities and skills of employees. Moreover, they are also looking to maximize their profits. Therefore, they provide best possible offers, contracts, training and development programs through professional lecturers and trainers so as to improve their own credibility. In addition to that, they also offer some special contracts including free contract for more employees, discounts for contracts having longer tenure etc. KforceInc – U.S based firm KforceInc provides professional and technical services specially for staffing companies. This company is primarily based upon four departments which include: Government Solution (GS), Technology (Tech), Health and Life Sciences and Finance and Accounting (FA). The two activities of Tech and FA are delivered in the specific regions of North, Atlantic and Western markets. Morson Group

Anil story Essay Example | Topics and Well Written Essays - 500 words

Anil story - Essay Example The boy’s state depict how fearful he was for what would happen in future. He is being forced to the city yet he really does not want to. By crying out loud and asking the questions, it is evident that he does not like what may happen when he is away. Some theme of fear has been described in this section. The writer describes Anin’s state and goes ahead to describe his feelings and imaginations. He believed there could be a ghost outside that will make him not return. Anin feared the dark and unforeseen circumstances. The fact that Anin did not dare go out of the house himself is proof enough that he did have fear. The Author develops this theme by using vivid description. He describes the ghostly tree and he fact that Anin made attempts to move out and came back. We are even told that Anin knew he would not return, which blankly develops this theme. The fact that Noor has described the feelings and emotions around Anin depicts instance of fear. This is a boy who has certainly watched the incident of suicide. In addition to this, the author brings out his body language that clearly shows that the boy was gripped with fear. This story further explores how the village people slept and dreamt from the opening paragraphs. Definitely this young boy lacked the sleep, creating the element of fear. Fear of exposure. In this section, Marimuthu definitely knew all was not well, someone had sported him. The Author describes his guilty looks and this brings the element of fear. In this category, the village headman and Anil’s also seem fearful of any repercussions because they know the death was not suicidal. Consider the sentences â€Å"I have to talk to you, Ragunathan. I have to talk to you about this son of yours† and ‘Are you sending me off because I saw him do it?’ These two show some element of fear thus the actions that transpired. The author has used onomatopoeia to create setting and environment of fear. The

The Apology Essay Example | Topics and Well Written Essays - 500 words - 1

The Apology - Essay Example 33. This paper evaluates Socrates’s reaction. An important philosophical issue raised here is whether the teachers can charge the students for their service of transferring knowledge to them?, because charging students for teaching them was one of the accusations made on Socrates. 34. Another philosophical issue is that if only the believers who consider their wisdom worth nothing are wise, then how do atheists compare with the believers who think that they are wise? Finally, if an individual is an expert in a field, can he be considered wise even if he has no expertise in other fields at all? According to Socrates, there is nothing wrong with a teacher taking money for passing knowledge onto the students. 34. Socrates has drawn upon the examples of numerous philosophers and educationalists like the Gorgias of Leontium who were paid teachers. 34. According to Socrates, atheists and believers who think that their wisdom is worthy belong to the same category of unwise people. 36. It is not about the presence or lack of belief in gods as gods are out of the equation. Socrates does not consider an individual who is expert in a specific field but not in others wise. 37. Socrates’s reaction seems to be based on a self concocted story. It seems like a joke that an oracle declared Socrates as the wisest person on Earth. Socrates might not have found them but we know many people who underestimate their knowledge even when they know much more than others do. Secondly, belief in Socrates’s story necessitates an assumption that Socrates was a know-it-all kind of person. Probably the poets had made the correct interpretations and explanations of their poetry but Socrates was too naà ¯ve to understand that depth and in turn, declared that the poets did not understand their own poetry. Although I do not quite believe in the story Socrates narrates in his defense, yet I support

Discuss the differences and similiraties for the characters, content Essay

Discuss the differences and similiraties for the characters, content and writing style for the Bluest Eye by Toni Morrison and - Essay Example The families are segregated and discriminated by the dominant society and pushed to take resort to isolation. It is the isolation that makes the parental characters violent, neglectful and careless to their children. In return, the children also are forced to isolate themselves from the family as well as from the society. The most haunting theme that both of the two novels contain is the association of whiteness with every sphere of a black’s life in a white dominated society. It is not a mere phenomenon of life; rather it is the prerequisite for love and romance; the standard of beauty, symbol of decency for Pecola. In the same manner, whiteness, especially, blond hair is the symbol of beauty. Since she is a fat black girl, she is in constant self-admonishment that she is ugly. Both of the two novels deal with the devastating impacts of color-based on the growth of teenage psychology as well as on the whole black community. The color-based racism misguides them to find their worth in color, that is, the beauty or whiteness of their skin. Whereas Pecola finds relief from this color-based beauty in her service a white woman’s home, Maya seeks relief and feels confidence in herself by learning to challenge the white dominance. Both of them feel that they are ugly and longs for beauty. But neither of the two can surpass the stern reality that they are black and therefore ugly by birth. Maya describes the unbearable pain of being segregated and humiliated by the whites in the following lines My race groaned. It was our people falling. It was another lynching, yet another Black man hanging on a tree. One more woman ambushed and raped. . . . This might be the end of the world. If Joe lost we were back in slavery and beyond help. It would all be true, the accusations that we were lower types of human beings. (Angelou 58) Indeed their tragic flaw lies in the fact that they taught by the society believe that beauty lies in whiteness. But when Maya learns a bout the insidious nature of racism and finds her worth in being able to revolt against this racism and learns that white beauty is nothing but the racial discrimination of the white society in which she lives, Pecola’s relief in working for the white woman dooms her further by deeply rooting the belief in her mind that she is cursed by birth and she can never have Caucasian blue eye and whiteness. Indeed Pecola blindfolded by her romantic notion of love that if she does not have the blue eye, she will not be loved, as the narrator says, â€Å"It had occurred to Pecola some time ago that if her eyes, those eyes that held the pictures, and knew the sights—if those eyes of hers were different, that is to say, beautiful, she herself would be different† (Morison 89). But she cannot perceive that the white definition of beauty and blue eye is essentially the result of racial discrimination. Therefore she further becomes vulnerable to an eternal depression. Indeed whe reas Maya gets vigorous support from her grandmother, Pecola is deprived of such familial support. In this regard, Pecola is in utter contrast with Claudia and Frieda who are mentally strong in the face of racial adversaries. They vigorously and actively take a stance against the discrimination as well as any adversaries of life. They continued to support Pecola

Ethics and Professional Code of Conduct Research Paper - 1

Ethics and Professional Code of Conduct - Research Paper Example Police chiefs and Sheriffs are responsible for integrity, ethics and morality in the police force. However, they are unable to supervise the juniors effectively necessitating other approaches like training. According to Popa, Naghi and Isopescu (2012), professional ethics is from the Greek words â€Å"Deontos† and â€Å"Logos† meaning, â€Å"What must be done† and â€Å"the science of†. It includes a set of rules and regulations, which all professionals in the government including the police must follow at all times. The objective of the professional code is to ensure professionals respect the rule of law, the natural law and moral rule (Popa, Naghi and Isopescu, 2012). Rule of law dictates what is right and wrong in accordance to the law (Popa, Naghi and Isopescu, 2012). The natural law dictates what is right or wrong naturally and morality dictates what is right or wrong basing on the accepted principles (Popa, Naghi and Isopescu, 2012). Professional ethics and integrity are important to the police for many reasons. One, the police swear to protect the interests of the people in a given jurisdiction when starting their career. In this case, they are indebted to ensure that all people feel safe in their homes businesses and across the jurisdiction (Kadleck, 2003). Second, failure to follow the set rules and laws may lead to injustice even when the police officers have good intentions (Kadleck, 2003). Thirdly, lacks of ethics and professional code of conduct weaken the society (Kadleck, 2003). In this case, when people realize something bad is happening in the society, they do not report because they know the relevant authorities will not address the issue accordingly. For example, when a person breaks the law and instead of police officers arresting and charging the person, they take bribe and free the person. If the society gets to know of such things, they would be sceptical

Econ2010 Assignment Example | Topics and Well Written Essays - 250 words

Econ2010 - Assignment Example Opportunity cost results from high commodity prices that make the purchasers unable to get their preferred commodities rather, they opt for other commodities. Speculation can be described as a means by which an individual makes decisions without having concrete evidence. An example of a speculation is that an individual buying the shares or shares of a company believes that he is making an investment. He might make a profit or a loss from the shares he buys from the company. When the price ceiling is at Pc, the market equilibrium is not reached, and the producers or suppliers accrue losses from the current prevailing prices. The impact of the lost gains of commerce is that producers or suppliers are discouraged from transporting their product into the market resulting to shortage of the products in the souk. An economic distortion is a situation when suppliers are allowed to charge their prices in the market because the government has stopped allocating its financial resources. The difference is that the landlords will not particularly benefit because the government will be controlling the prices that they are charging to tenants (Kahn, 123). Loss of price floor policy will mean that individuals will have possession of various goods that may positively or negatively affect the state. An example is that teenagers in the society will have access to alcoholic beverages. Exporting a commodity refers to the process where a product is being transported out of the country. It is advantageous to export a product under a price floor policy because it relives exporters from paying taxes. Protectionism is a law that is placed to protect its citizen’s welfare in trade matters and jobs from foreigners and international trade by the government. An example is that the law gives a country’s citizen a higher opportunity of getting a job within the country than a foreigner (Kahn, 11). The cost of protectionism is expensive to the countries applying the

Ethics and Professional Code of Conduct Research Paper - 1

Ethics and Professional Code of Conduct - Research Paper Example Police chiefs and Sheriffs are responsible for integrity, ethics and morality in the police force. However, they are unable to supervise the juniors effectively necessitating other approaches like training. According to Popa, Naghi and Isopescu (2012), professional ethics is from the Greek words â€Å"Deontos† and â€Å"Logos† meaning, â€Å"What must be done† and â€Å"the science of†. It includes a set of rules and regulations, which all professionals in the government including the police must follow at all times. The objective of the professional code is to ensure professionals respect the rule of law, the natural law and moral rule (Popa, Naghi and Isopescu, 2012). Rule of law dictates what is right and wrong in accordance to the law (Popa, Naghi and Isopescu, 2012). The natural law dictates what is right or wrong naturally and morality dictates what is right or wrong basing on the accepted principles (Popa, Naghi and Isopescu, 2012). Professional ethics and integrity are important to the police for many reasons. One, the police swear to protect the interests of the people in a given jurisdiction when starting their career. In this case, they are indebted to ensure that all people feel safe in their homes businesses and across the jurisdiction (Kadleck, 2003). Second, failure to follow the set rules and laws may lead to injustice even when the police officers have good intentions (Kadleck, 2003). Thirdly, lacks of ethics and professional code of conduct weaken the society (Kadleck, 2003). In this case, when people realize something bad is happening in the society, they do not report because they know the relevant authorities will not address the issue accordingly. For example, when a person breaks the law and instead of police officers arresting and charging the person, they take bribe and free the person. If the society gets to know of such things, they would be sceptical

Functional organizations are described by organizational charts Essay

Functional organizations are described by organizational charts. Explain why a temporary organization such as a project can benefit from using an organizational chart - Essay Example lpful where projects involve various departments and participants who have to coordinate their work or when they are required to report to a person from a different department. Some projects involve working with new faces and one has to learn to recognize these new faces for better efficiency under these circumstances, an organizational chart comes in handy because it not only has the faces of the participants of the project but also their names and their different roles not to mention it provides a constant reference point. An organizational structure helps in better management of resources and personnel by preventing duplication of roles and capacities moreover, it helps reduce the work load of managers and supervisors as it shows the number of people they have to supervise and the various departments that have to report to them. If the project is to take a considerable length of time, an organizational chart is used by project participants to see their promotion options and the vacancies that surround them. This way they don’t have to miss out of opportunities that they can easily take advantage

Macbeth Blind Ambition Essay Example for Free

Macbeth Blind Ambition Essay The tragedy, ‘Macbeth’, composed by William Shakespeare is a play of manipulation and blind ambition. This is clearly depicted through the character of Macbeth, a great man fallen from God’s grace. Initially, Macbeth’s is presented as a character with noble qualities, who earns himself the trust of King Duncan and admiration of his people. However, the meeting with the weird sisters takes a toll on his personality for the worse, as they ambiguously prophesise that Macbeth will become King of Scotland. Upon hearing this, Macbeth takes fate into his own hands and embarks on a journey of blind ambition. Ultimately, Macbeth’s character deteriorates and is destined to fall. Therefore, through the dramatic elements of the play, we anticipate the downfall of valiant Macbeth as a ramification of the fatal flaw of blind ambition. Blind ambition comes at the cost of our humanity. Macbeth aligns himself with the supernatural elements, which are associated with darkness and evil. Originally, Shakespeare introduces Macbeth as a great man, as depicted through the similes of Yes, as sparrows eagles, or the hare the lion and â€Å"Signs of nobleness, like stars, shall shine†¦Ã¢â‚¬  This reflects Macbeth’s bravery, as he is bequeathed the gift of stars by King Duncan. Quite soon, however; we witness how he morphs into a two-faced, conniving snake, as illustrated through this simile â€Å"Look like the innocent flower, But be the serpent under it. † The audience immediately recognises the disparity between the dark supernatural elements and the elements of goodness and light. We expect the power play will be evoked through the illusions and half-truths through the paradox of â€Å"Fair is foul, and foul is fair. † A strong illusion that Shakespeare evokes to dramatise the mental state of Macbeth is the dagger soliloquy, â€Å"Is this a dagger which I see before me. † Whilst we see him in inner conflict over his intention to assassinate King Duncan, we recognise that he will not deviate from the path of darkness as he calls on the stars as seen through the apostrophe â€Å"Stars, hide your fires, Let not light see my black and deep desires’. This establishes that Macbeth represents darkness and this contrasts to Duncan, as he is a symbolism of light. Through the apostrophe, â€Å"Come spirits, unsex me†, we perceive that Macbeth and Lady Macbeth align themselves to the supernatural world for power, and in return they are stripped off of their humanity. Shakespeare dramatises these events to challenge us to consider of ramifications of blind ambition. Taking destiny into one’s hands for self gain may lead to self annihilation, and unnatural chaos ensues. Once regicide is committed, Macbeth is overwhelmed by nausea, as he has â€Å"murdered sleep. He then realises the magnitude of his sins, as it is emphasised through this hyperbole â€Å"Will all Great Neptune’s ocean wash this blood clean from my hand? † This imagery is juxtaposed with the litotes of â€Å"A little water will clear us of this deed. † Therefore, pathos is established between Macbeth and Lady Macbeth, as they are anointe d by blood through the act of regicide, â€Å"My hands are of your colour†. Dramatic irony is established as we know that this couple can never be extricated from guilt. With little remorse, he embarks on a journey of self destruction and mass murder. There is no salvation for him, and this is clearly demonstrated through the metaphor â€Å"Stepped in so far, that, should I wade no more. † He repeats his mistakes as he continues the assassinations of the innocent, and his sins further escalate when he slain Macduff’s family. However, the further they continue on the path to darkness, the more plagued they are by the blood seeping from their hands, â€Å"Out, damned spot! † Macbeth also hallucinates and is haunted by Banquo’s ghost. This can be demonstrated through the imagery â€Å"Quit my sight! Let the earth hide thee† Unnatural chaos ensues as a result of King Duncan’s death and Macbeth’s unnatural deeds due to blind ambition. This is evoked through the disorderly image of and â€Å"Unnatural deeds do breed unnatural troubles. † Until another great being can overthrow tyrannical Macbeth, then the violation of nature’s order will not be restored. Shakespeare invites us to consider the law of ‘cause and effect’. Blind ambition overrides Macbeth’s rational mind and any sense of inherent moral sensibility. Lady Macbeth and Macbeth are left tormented as they cannot sustain inner peace and sleep, â€Å"Sleep no more! which leads them to the brink of insanity. Furthermore Macbeth acknowledges that Duncan is at peace in the liberation of death, and he dramatises the inner conflict and insecurity through the paradox â€Å"To be thus is nothing, but to be safely thus. † This foreshadows the downfall of Macbeth and soon he will be released from his torment. Blind ambition robs Macbeth’s foresight and without realising it, it puts a strain on his and his wife’s marriage. Macbeth and Lady Macbeth’s mental deterioration is emphasised through their severed relationship. As a result of blind ambition, Lady Macbeth resorts to suicide. She lives in fear, as she is constantly plagued from the murder. Therefore, death is her release. Shakespeare invites us to evaluate our behaviour and challenge us to take responsibility for our own actions. As a result of blind ambition, Macbeth is trapped in an illusion of perception versus reality. He consolidates his relationship with the supernatural elements. The witches present three apparitions, which include the â€Å"armed-head†, â€Å"bloody child† and the â€Å"boy with a crown and a tree from his hand. This directs Macbeth to the road of self-annihilation, and through the half-truths, dramatic irony is established and this serves to heighten tension, as the audience expects the downfall of Macbeth. Macbeth is struggling to find the purpose to live, as exemplified through litotes of â€Å"Out, brief candle†. He compares his life to a â€Å"brief candle† that is easily blown out by the wind and it connotes that human life is uncertain. â€Å"Tomorrow, and tomorrow, and tomorrow,† Macbeth laments on the loss of his future, as he comes to term of his inevitable demise. Therefore, Macbeth is associated with pathos, and as an audience, we do pity his pathetic being. In the climax of the play, Macbeth is confronted by noble Macduff and it is revealed that the witches’ ambiguous prophecies were half-truths and Macbeth was so wrapped up in his own illusion that he could not see through it. As a result, it led to his downfall. The catharsis is established when Macduff defeats Macbeth and claims justice to Scotland. Shakespeare writes to raise awareness that some things are not what they appear to be. By the end of the play, we witness the downfall of Macbeth as a result of blind ambition. Blind ambition robs Macbeth of his humanity and foresight, and because of this, Macbeth’s character has deteriorated, as his deterioration is manifested through acts of massacres. In the end, Macbeth does not fully redeem himself, although he does hold regret for the heinous deeds he has committed, and therefore, he dies an undignified death. Hence, Shakespeare invites us consider the natural cycle of ‘cause and effect’ and how acts of blind ambition can lead to deadly consequences.

Testing Drug Content of Famotidine Core Tablets

Testing Drug Content of Famotidine Core Tablets 6. Formulation development and evaluation 6.1 Preparation of core tablets Core tablets of famotidine were prepared by direct compression and batch size was kept as 100 tablets. Drug , sodium chloride, polymer and MCC were co-sifted through sieve # 30 Now the blend is mixed in polybag for 10 min Citric acid was crushed using mortar and pestle and sifted through sieve # 60 And this is added to above blend and mixed in a polybag for 10 min. Then magnesium stearate talc were passed through sieve #60 and to the above blend and mixing continued for another 2 min Now the blend is compressed to tablets having the average weight of 180 mg using 8 mm round concave punch and at low relative humidity 20 % RH 6.2 Coating of core tablets: 6.2.1. Preparation of coating solution: 5 ml of water was taken in a beaker and to this required amount of PEG 400 was added and dissolved 95 ml of acetone was taken in a beaker and stirred at 150 rpm using electrical stirrer to this above solution was added and stirred for 5 min Now to the above solution 5 gm of cellulose acetate was added slowly and stirring is continued for another 30 min i.e until a clear solution was formed. 6.2.2. Procedure for coating of semi permeable membrane: Coating was done using RD Lab Coater. Core tablets were placed in the coating pan and coated with cellulose acetate solution coating parameters are maintained as below: Inlet temperature : 40 oC  ± 2 oC Bed temperature: 35 oC rpm of pan: 15 -17 Spray rate: 3-7 ml/min Atomizing air pressure: 2.0 psi Coating was done until required weight gain was achieved Drilling of orifice: The orifice was made using needles of different sizes i.e, 24, 22 guage INGREDIENTS F1 F2 F3 F4 F5 F6 Core tablet mg/tablet Famotidine 40 40 40 40 40 40 Citric acid 20 20 20 20 20 20 Sodium chloride 50 50 50 50 50 50 HPMC k100M 9 18 Polyox1105 7.2 Polyox 301 7.2 Polyox303 7.2 Sodium lauryl sulphate 3.6 3.6 3.6 3.6 3.6 3.6 Magnesium stearate 1.8 1.8 1.8 1.8 1.8 1.8 Talc 3.6 3.6 3.6 3.6 3.6 3.6 Avicel PH 102 43 43 53.8 53.8 53.8 53.8 Total wt of tablet 180 180 180 180 180 180 Coating solution Cellulose acetate 5 gm 15 % w/w of total solids (0.669 ml) 4 ml Upto 100 ml 4% PEG 400 Water Acetone Weight gain Coated tablets were left over night for drying Table 6.8 Formulation trails for optimum polymer (using various grades of HPMC and PEO) Table6.9 Formulation trails for optimum polymer concentration and coating weight gain INGREDIENTS F7 F8 F9 Core tablet mg/tablet Famotidine 40 40 40 Citric acid 20 20 20 Sodium chloride 50 50 50 Polyox 301 10.8 10.8 10.8 Avicel PH 102 50.8 50.8 50.8 Sodium lauryl sulphate 3.6 3.6 3.6 Magnesium stearate 1.8 1.8 1.8 Talc 3.6 3.6 3.6 Total wt of tablet 180 180 180 Coating solution Cellulose acetate 5 gm PEG 400 15 % w/w of total solids (0.669 ml) Water 4 ml Acetone Upto 100 ml Weight gain 4 % 3 % 5 % Table 6.10 Formulation trails of optimum plasticizer concentration INGREDIENTS F 10 F 11 F 12 Core tablet mg/tablet Famotidine 40 40 40 Citric acid 20 20 20 Sodium chloride 50 50 50 Polyox 301 10.8 10.8 10.8 Avicel pH 102 50.8 50.8 50.8 Sodium lauryl sulphate 3.6 3.6 3.6 Magnesium stearate 1.8 1.8 1.8 Talc 3.6 3.6 3.6 Total wt of tablet 180 180 180 Coating solution Cellulose acetate 5 gm 5 gm 5 gm PEG 400 (% w/w of total solids) 20% (0.89 ml) 25% (1.25 ml) 35% (1.4 ml) Water 4 ml 4 ml 4 ml Acetone Upto 100 ml Upto 100 ml Upto 100 ml Weight gain 4% 4% 4% 6.3 Evaluation of blend 6.3.1 Angle of repose Angle of repose: Weighed quantity of the drug was passed through a funnel kept at a height 2 cm from the base. The powder is passed till it forms a heap and touches the tip of the funnel. The radius the base of the conical pile, and the height of pile were measured and the angle of repose was calculated using the formula: (h/r) h = height of the pile r = radius of the base of the conical pile Table 6.4 Flow property and corresponding angle of repose Flow property Angle of repose (ÆÅ ¸) Excellent 25 – 30 Good 31 – 35 Fair-no need of aid 36 – 40 Passable –hang up chances 41 – 45 Poor – must vibrate, agitate 46 – 55 Very poor 56 – 65 Very, very poor >66 Formulation code Angle of repose F1 25.45 F2 22.92 F3 23.13 F4 19.20 F5 18.62 F6 17.20 F7 20.09 Table no. : Data for angle of repose of all formulations 6.3.2 Bulk density An accurately weighed quantity of powder carefully poured into graduated cylinder. Then after pouring the powder into the graduated cylinder the powder bed was made uniform without disturbing. Then the volume was measured directly from the graduation marks on the cylinder as ml. The volume measure was called as the bulk volume and the bulk density is calculated by following formula: Bulk density = Weight of powder / Bulk volume Tapped Density: After measuring the bulk volume the same measuring cylinder was set into tap density apparatus. The tap density apparatus was set to 300 taps drop per minute and operated for 500 taps. Volume was noted as (Va) and again tapped for 750 times and volume was noted as (Vb). If the difference between Va and Vb not greater than 2% then Vb is consider as final tapped volume. The tapped density is calculated by the following formula: Tapped density = Weight of powder / Tapped volume Compressibility Index: It gives the flow property of the granules. More is the compressibility; less will be the flow property. It was calculated by the following formula using previously obtained bulk and tapped densities. Carrs index = Tapped density Bulk density X 100 Tapped Density Hausner Ratio: It is used for flow property of the granules. It was also calculated from bulk and tapped densities using following formula: Hausners ratio = Tapped density / Bulk density Table 6.3 Flow property and corresponding Carrs index Hausner ratio Flow property C.I ( % ) Hausner ratio Excellent ≠¤10 1.00 – 1.11 Good 11 – 15 1.12 – 1.18 Fair 16 – 20 1.19 – 1.25 Passable 21 – 25 1.26 – 1.34 Poor 26 – 31 1.35 – 1.45 Very poor 32 – 37 1.46 – 1.59 Very, very poor >38 >1.60 Formulation code Bulk density (gm/cm3) Tapped density (gm/cm3) Carr’s index (%) Haussners ratio Angle of repose F1 0.486 0.631 22.9 1.25 25.45 F2 0.410 0.513 20.08 1.25 22.92 F3 0.438 0.601 18.259 1.18 23.13 F4 0.436 0.583 16.39 1.196 19.20 F5 0.430 0.520 17.31 1.21 18.62 F6 0.462 0.535 13.64 1.16 17.20 F7 0.446 0.523 14.72 1.17 20.09 Table no. : Data for Bulk density, Tapped density, Compressibility index and Hausner’s ratio of all formulations 6.4 Post compression studies 6.4.1 Weight variation The average weight of core tablets and coated tablets were determined using a digital weighing balance. 20 tablets were selected randomly from each batch and weighed individually, calculating the average weight and comparing the individual tablet weight to the average. From this, percentage weight difference was calculated. Table 6.11 Limits of weight variation IP/BP Limit USP 80 mg or less 10% 130mg or less More than 80mg or Less than 250mg 7.5% 130mg to 324mg 250mg or more 5% More than 324mg Table no. : Data for weight variation test of all formulations Formulation Code Avg weight (mean ±%deviation) Before Coating After Coating F1 178.42 ± 1.02 185.72 ±1.12 F2 181.31 ± 0.91 188.79 ±1.45 F3 179.21 ±1.34 187.89 ±1.09 F4 181.39 ±0.98 189.01 ±0.98 F5 179.76 ±1.32 186.96 ±1.42 F6 183.12 ±2.24 190.32 ±1.08 F7 180.09 ±1.08 187.34 ±1.12 F8 178.12 ±1.24 184.52 ±1.33 F9 179.35 ±1.02 187.01 ±1.14 F10 180.45 ±0.98 188.00 ±1.11 F11 181.32 ±1.23 188.67 ±1.28 F12 182.45 ±1.11 189.79 ±1.20 Hardness Hardness indicates the ability of a tablet to withstand mechanical shocks while handling. Hardness of both core and coated tablets were determined using a Monsanto hardness tester. It is expressed in kg/cm2. Three tablets were randomly picked from each batch and analyzed for hardness. The mean and standard deviation were also calculated. Table no. : Data for hardness of all formulations Formulation Code Hardness (kg/cm2)(n=3) (mean ±SD) Before Coating After Coating F1 5.06 ±0.19 6.18 ±0.22 F2 5.21 ±0.26 6.29 ±0.42 F3 4.96 ±0.32 6.03 ±0.15 F4 5.02 ±0.22 6.41 ±0.32 F5 5.28 ±0.18 6.17 ±0.18 F6 5.11 ±0.33 6.25 ±0.28 F7 4.89 ±0.25 6.00 ±0.33 F8 4.99 ±0.14 6.32 ±0.36 F9 5.08 ±0.18 6.75 ±0.25 F10 4.99 ±0.25 5.98 ±0.12 F11 5.12 ±0.33 5.90 ±0.21 F12 4.97 ±0.10 5.96 ±0.19 Friability (F) It is the phenomenon whereby tablet surfaces are damaged and/or show evidence of lamination or breakage when subjected to mechanical shock or attrition. The  friability of core tablets was determined using Roche Friabilator. It is expressed in percentage (%). Twenty core tablets were initially weighed (Winitial) and transferred into friabilator. The friabilator was operated at 25 rpm for 4 minutes or run up to 100 revolutions. The tablets were weighed again (Wfinal). The % friability was then calculated % Friability = ((A-B)/A) Ãâ€" 100 Where, Formulation Code Friability (%) (n=10) F1 0.010 F2 0.015 F3 0.017 F4 0.012 F5 0.009 F6 0.016 F7 0.014 F8 0.013 F9 0.012 F10 0.015 F11 0.014 F12 0.012 A = Initial weight of tablets B = Final weight of tablets after 100 revolutions Friability of tablets less than 1% are considered acceptable. Drug content The famotidine core tablets were tested for their drug content. Five tablets were finely powdered; quantities of the powder equivalent to 100 mg of famotidine were accurately weighed and transferred to a 100 ml of volumetric flask. Made up to 100ml with 4.5 phosphate buffer. From the above solution 1ml was taken and made up to100 ml with phosphate buffer (pH 4.5) From the above solution 10 ml was taken and made up to100 ml with phosphate buffer (pH 4.5) i.e.,10 µg/ml solution and measure the absorbance of the resulting solution at 265 nm using a Shimadzu UV-visible spectrophotometer. The linearity equation obtained from calibration curve was used for estimation of famotidine in the tablet formulations. Formulation Code Assay (%) F1 99.25 ±0.042 F2 98.32 ±0.052 F3 99.15 ±0.016 F4 99.52 ±0.019 F5 101.95 ±0.021 F6 99.25 ±0.034 F7 99.98 ±0.028 F8 98.74 ±0.052 F9 98.23 ±0.061 F10 100.12 ±0.011 F11 99.52 ±0.021 F12 99.56 ±0.023 Table no. : Data for drug content of all formulations In-Vitro Dissolution Studies The developed formulations of were subjected in vitro dissolution studies using USP Type II dissolution apparatus (Electrolab, India) with a speed of 50 rpm. The dissolution study was carried out in 900 ml dissolution media maintained at 37 ±0.5 oC. At suitable time interval, 10 ml samples were withdrawn and replaced with equivalent amount of fresh medium to maintain sink conditions. Samples withdrawn were filtered and analyzed at 265 nm using a UV spectrophotometer. After analyzing the drug content in the dissolution samples, cumulative percentage of drug release versus time was plotted. The general conditions for in vitro dissolution studies are as summarized below. Dissolution conditions: Medium : 4.5 phosphate buffer Volume: 900 ml Temperature: 37  °C  ± 0.5  °C Apparatus: USP Type-II (paddle) Rpm: 50 Time intervals : 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 12 hr Samples were suitably diluted and absorbance was measured. Cumulative percentage drug released was calculated for each batch. The study was performed in triplicate and the average was reported. Table no. : In-Vitro data drug release data for formulation F-1 S.no Time Cumulative % drug release 1 0 0 2 1 2.81 ±2.75 3 2 4.00 ±1.64 4 3 6.67 ±2.56 5 4 10.61 ±1.98 6 5 13.07 ±2.84 7 6 16.31 ±1.27 8 7 18.56 ±1.32 9 8 21.86 ±0.99 10 10 27.07 ±1.46 11 12 32.76 ±1.21 Figure no. : In-Vitro drug release of formulation F-1 Table no. : In-Vitro data drug release data for formulation F-2 S.no Time Cumulative % drug release 1 0 0 2 1 2.10 ±2.84 3 2 4.21 ±1.95 4 3 7.52 ±2.95 5 4 10.61 ±2.09 6 5 13.07 ±1.95 7 6 16.31 ±2.75 8 7 18.56 ±2.94 9 8 21.86 ±1.24 10 10 32.16 ±1.89 11 12 40.79 ±1.11 Figure no. : In-Vitro drug release of formulation F-2 Table no. : In-Vitro data drug release data for formulation F-3 S.no Time Cumulative % drug release 1 0 0 2 1 4.02 ±3.72 3 2 8.04 ±1.34 4 3 13.34 ±2.83 5 4 18.63 ±1.52 6 5 22.90 ±1.32 7 6